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Robotic hand inserting snipped of DNA into a double helix
A New Way to Control Stem Cell Fate Using Gene Circuits
Scientists engineered human pluripotent stem cells with synthetic gene circuits to control differentiation without human input.
A New Way to Control Stem Cell Fate Using Gene Circuits
A New Way to Control Stem Cell Fate Using Gene Circuits

Scientists engineered human pluripotent stem cells with synthetic gene circuits to control differentiation without human input.

Scientists engineered human pluripotent stem cells with synthetic gene circuits to control differentiation without human input.

transplants

A clinician holding a graphic of the lungs on a tablet
Stem Cells Breathe New Life into Lungs
Aparna Nathan, PhD | Oct 30, 2023 | 3 min read
New studies proposed using stem cells to make long-lasting lung grafts.
an image of a slice of a rat brain is colored red on a black background. a lime green human organoid sits in the top left of the brain
Human Brain Organoids Transplanted Into Rats Respond to Visual Stimuli
Katherine Irving | Feb 3, 2023 | 3 min read
The organoids could one day be used to treat brain injuries in humans. 
Learn about hot topics in organoid research
Next-Level Organoids
The Scientist’s Creative Services Team | 1 min read
Researchers use organoid cultures in unique ways to study health and disease.
a section of a rat brain is imaged in dull green. a much brighter green human organoid takes up a large portion of the left side of the brain.
Researchers Transplant Human Neurons into Rat Brains
Katherine Irving | Oct 12, 2022 | 2 min read
The human cells, engineered to respond to blue light, influenced rat behavior when stimulated.
Bacteria on the skin
Biotech Tries Manipulating the Skin Microbiome
Bianca Nogrady | Apr 18, 2022 | 8 min read
Researchers are revealing the complexity of the microbial community living on the body—and paving the way for new bacteria-targeting treatments for acne and other dermatological conditions.
Cell Culture Advances Fuel Disease Research
The Scientist’s Creative Services Team | 1 min read
New twists to an old technique reveal a better understanding of disease pathology and new therapeutic avenues.
Abstract geometric heart with plexus effect on blue background
Man Receives Transplanted Heart from Genetically Modified Pig
Shawna Williams | Jan 10, 2022 | 3 min read
The procedure, performed last Friday, is a milestone in a long effort to boost the number of organs available for safe transplantation.
Collage of those featured in the article
Remembering Those We Lost in 2021
Lisa Winter | Dec 23, 2021 | 5 min read
As the year draws to a close, we look back on researchers we bid farewell to, and the contributions they made to their respective fields.
Human kidney in hands stock photo
Surgeons Successfully Transplant a Pig Kidney into a Person
Chloe Tenn | Oct 20, 2021 | 2 min read
The achievement bolsters hopes that nonhuman animals could be used to remedy the shortage of transplantable organs.
Pink-toned illustration of the uterus with a zoom of the inflamed cervix and of the uterine endometrium and immune cells found there
Infographic: Research Questions to Be Tackled by Uterus Transplants
Jef Akst | Aug 1, 2021 | 2 min read
Scientists are banking various samples from recipients of donated uteruses to learn all they can about the biology of the organ, and about transplantation more generally.
An illustration of flowers in the shape of the female reproductive tract
Uterus Transplants Hit the Clinic
Jef Akst | Aug 1, 2021 | 10+ min read
With human research trials resulting in dozens of successful deliveries in the US and abroad, doctors move toward offering the surgery clinically, while working to learn all they can about uterine and transplant biology from the still-rare procedure.
Barbara Murphy wearing a white lab coat, facing the camera with a blue background
Nephrologist Barbara Murphy Dies at 56
Lisa Winter | Jul 6, 2021 | 2 min read
Her work led to more predictable outcomes for kidney transplants.
ethics, bioethics, brain organoid, chimera, cell transplant, Q&A, report, NIH, NAS, neuroscience, Techniques, disease & medicine, immunology, psychiatric conditions
New Report Dissects Ethics of Emerging Human Brain Cell Models
Amanda Heidt | Apr 12, 2021 | 5 min read
The National Academies’ report touches on ethical issues raised by new technologies such as brain organoids and human-animal chimeras, and suggests that current regulatory oversight is sufficient.
Organoids Repair Bile Ducts
Abby Olena, PhD | Feb 18, 2021 | 4 min read
Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally.
acute myeloid leukemia aml baking soda sodium bicarbonate nabi bicarb t cell transplant stem cell infusion lactic acid cytokine ph acidosis
Baking Soda Boosts T Cells’ Ability to Fight Leukemia
Rachael Moeller Gorman | Nov 2, 2020 | 4 min read
Infusions of donor T cells to fight the cancer often fail, but sodium bicarbonate can counter lactic acid produced by leukemia cells, potentially improving remission rates in mice and humans.
Transplant Method Avoids Rejection of Donor Leg for Months in Rats
Abby Olena, PhD | Mar 13, 2020 | 4 min read
A proof-of-concept study uses a strategy similar to the way tumors evade immune detection. The new limbs survive for more than 200 days.
the torso and head of a man being 3-D printed
On the Road to 3-D Printed Organs
Emma Yasinski | Feb 26, 2020 | 6 min read
Researchers can print cells and biomaterials that make up human tissues, but there’s still a long way to go before fully functional organs can be made to order.
Pelizaeus-Merzbacher disease neural stem cell transplantation
Neural Stem Cell Transplantation Crawls Toward the Clinic
Ashley P. Taylor | Oct 29, 2019 | 9 min read
Several early-stage clinical trials indicate that implanting patients with the cells is safe. But whether they can alleviate neurological problems remains to be seen.
cornea ipsc induced pluripotent stem cells corneal transplant eye disease
Woman Receives First Corneal Transplant Made from iPS Cells
Emily Makowski | Sep 3, 2019 | 2 min read
The patient’s vision has improved since the procedure, and her cornea remains clear.
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