T cell

What underlies the uneven burden of autoimmunity between the sexes has remained a mystery. Now, scientists found clues by turning to a key player on the X chromosome.

Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.

Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.

Regulatory T cells in the colon travel to muscles to promote wound healing in mice, raising questions about how antibiotics may impact injury recovery.

Two studies find that tumor-specific antigens are often peptides that result from a splicing event between exons and transposable elements.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

Immunoglobulin genes might have evolved much earlier than previously expected, perhaps even in the common ancestor of Cnidarians and Bilateria, a study suggests.

Researchers found that naturally-occurring CD7-negative T cells avoid self-destruction and are good effectors in CAR T therapy for T cell blood cancers.

Immune cells deliver packages of telomeres to T cells, helping them retain their virus-fighting function over time, research suggests.

The results could help guide the design of new vaccines for the disease.

Researchers find that tissue-resident memory T cells in the corneas of mice engender a lasting immune response.

Deletions in the sleepy lizard genome leave it without an important type of T cells found in most other vertebrates.

Roseolovirus infection disrupts how the body trains immune cells not to attack it, a mouse study shows.