RNA sequencing

Researchers developed and validated a sequencing method for mRNA vaccines, moving the manufacturing field forward by linking established technologies with translational applications.

Researchers find that UBQLN2 gene dysfunction causes a virus-like protein to accumulate in cells, which changes gene expression and may contribute to disease progression in amyotrophic lateral sclerosis (ALS).

Two studies find that tumor-specific antigens are often peptides that result from a splicing event between exons and transposable elements.

A study identifies nearly 3,000 genes where one allele tends to be expressed more than the other, but the findings ignited controversy in the field. 

Where and how human papillomavirus integrates itself into the human genome steers the infection’s clinical outcomes, finds a large, multifaceted study.

The MIT biologist studies how RNA molecules self-assemble and the role these accumulations may play in diseases such as ALS and Huntington’s.

A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.

The molecular biologist studies how chemical modifications to RNA building blocks change the way RNA regulates complex cellular processes.

A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.

RNA sequencing technology lags far behind researchers’ ability to decode and understand DNA. The COVID-19 pandemic has highlighted this dangerous shortcoming.

Influenza RNA sequences from three sets of lungs preserved in formalin since 1918 provide new insights into the deadly pandemic.

In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.

The presence of a particular set of RNAs in the blood forewarns of an onset of severe symptoms and points to the cells involved.