lysosomes

New innovations for reducing nonspecific fluorescence offer researchers clearer pictures and more multiplexing possibilities.

The Scientist spoke with Jonathan Kagan about his idea that immune cells respond to “errors” made by unsuccessful pathogens, not the pathogens themselves.

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.

A team of scientists has found that in mice, a cellular housekeeping pathway protects against a major cause of heart attacks and strokes.

Testing in animals and lab-grown cells suggests the experimental drug could enhance the function of lysosomes within cells.

A study finds that β-coronaviruses don’t use the normal secretory pathway, a possible explanation for some aspects of COVID-19 pathology.

New evidence points to a waste-clearing problem in patients’ cells, rather than the accumulation of protein tangles, as the root cause of the neurodegenerative disease.

Damage to the lysosome, the organelle that removes excess proteins, lipids, and other materials, might be at the root of the disease.

To chew up waste in far-reaching dendritic spines, lysosomes are trafficked sometimes hundreds of microns away from the cell bodies of neurons in rats. 

Scientists studying the basic molecular steps of Ebola infection identify a mammalian protein that is essential for the pathogen to infect mice.

By audaciously pursuing an abandoned area of research, Ana María Cuervo discovered how cells selectively break down their waste, and revealed the health consequences when that process malfunctions.

Christian de Duve chose to be euthanized at home in Belgium at age 95.

Two proteins interact to save adhesion molecules from degradation, potentially contributing to a more aggressive cancer.

Despite years of research, the longstanding mystery of where the autophagosome gets its double lipid bilayers is not much clearer.