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Professor Sir Ian Wilmut with Dolly the sheep

Ian Wilmut, Famed Scientist Who Led the Creation of Dolly the Sheep, Died at 79

Shelby Bradford, PhD | Sep 12, 2023 | 3 min read

Knighted in 2008, Sir Ian Wilmut revolutionized the field of cloning, stem cell research, and regenerative medicine.

Image of spatial transcriptomic spots superimposed onto a stained tissue section.

Poor Cancer Prognosis Associated with a Transcriptional Signature

Charlene Lancaster, PhD | Sep 11, 2023 | 4 min read

Researchers connect a tumor’s leading edge transcriptional profile to poor survival outcomes across cancer types.

Smart Gateways into the Lab of the Future

The Scientist’s Creative Services Team | 2 min read

Neurobiologists, computer scientists, and engineers join forces to grow mini brains using automation and make their technologies smarter with artificial intelligence.

An elderly person in beige shirt and a knitted, cream-colored vest holds a wooden walking stick.

New Epigenetic Clocks May Confirm Extreme Age

Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read

How will a new version of epigenetic clocks aimed at validating the age of people older than 100 years of age balance accuracy and anonymity?

A computer-generated image of chromosomes on a black background. One chromosome has a ring of bright orange to indicate a mutation.

Prime Editing Comes of Age

Ida Emilie Steinmark, PhD | Sep 8, 2023 | 9 min read

Since the technique was first published in 2019, prime editing has grown with lightning speed, alongside hopes for what it can achieve.

The Scientist's Journal Club: Transcriptomics

The Scientist’s Creative Services Team | 2 min read

Scientists discuss their latest findings on immune cell dynamics, neurodegenerative disease risk factors, and rare cell types obtained from bulk and single cell RNA sequencing experiments.

A man sitting at a desk in a white lab coat holds up a large model of a <em >Drosophila</em> fly. In the background is a window and a bookcase.

The Origins and Recent Promise of Nonsense Suppressor tRNAs

Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read

A discovery that goes back to the first studies of translation has become the topic of biotech buzz.

The prime editing machinery comprises a prime editing guide RNA (pegRNA) and a Cas9 nickase enzyme fused to a reverse transcriptase.

Infographic: How Prime Editing Works

Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read

Prime editing is one of the most promising forms of genome editing because it uses only single-stranded DNA breaks.

Team of Medical Research Scientists Collectively Working on a New Generation Experimental Drug Treatment. Laboratory Looks Busy, Bright and Modern.

Next-Generation Sequencing: A World without Limits

The Scientist’s Creative Services Team and Illumina | 5 min read

Centralized core facilities and commercial service providers specializing in NGS provide expertise and training for researchers new to the method.

This shows a cryo-EM map of a Fanzor protein in complex with its guiding RNA (in purple) and DNA (target strand in red, complementary strand in blue).

CRISPR-like Abilities in Eukaryotic Proteins

Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read

Two groups independently discovered that Fanzor proteins in eukaryotic organisms are CRISPR’s genome-editing cousins.

A photo of the PlatinumTM Next-Generation Protein Sequencer, a small roughly cube-shaped blue-black-silver instrument.

Breaking Down Barriers to Protein Sequencing

The Scientist Staff | Sep 1, 2023 | 2 min read

Next-generation protein sequencing is becoming more powerful, streamlined, and accessible.

Discover how a cellphone-driven UV gel documentation system accelerates accessible imaging.

Accessible Gel Imaging with a Cellphone

Analytik Jena | 1 min read

In the classroom or the laboratory, a new gel documentation system enables scientists to capture snapshots of their samples in real time.

The Oligo Was a No Go

Danielle Gerhard, PhD | Sep 1, 2023 | 2 min read

As soon as Melanie McConnell added the wash buffer to her sample, she knew she had made a mistake.

This is an image of a bioluminescent from gene expression reporter in stem cells from a rhinoceros.

A Stem Cell Zoo Reveals Surprising Differences in Embryogenesis

Ida Emilie Steinmark, PhD | Sep 1, 2023 | 2 min read

By comparing stem cells from six mammals of different sizes, scientists discovered stark differences in embryonic development paces.

Equally-sized droplets of a nucleic acid sample.

Digital PCR: The Journey to Superior Data

Bio-Rad Laboratories | 1 min read

With digital PCR (dPCR), researchers accurately and precisely quantitate nucleic acid samples.

The illustration shows floating chromosomes with a Y-shaped chromosome in the foreground.

Closing the Gaps in the Human Genome: Why Y Was the Final Hurdle

Kamal Nahas, PhD | Aug 28, 2023 | 4 min read

For two decades, scientists struggled to fully sequence the Y chromosome. Finally, researchers have mapped its full length thanks to recent advances in sequencing technology.

A dart board with on dart on the bullseye and several scattered darts that missed the target

Predicting the Next Level of CRISPR Control

Deanna MacNeil, PhD | Aug 28, 2023 | 3 min read

Scientists combine the power of genome-wide screens and machine learning to unlock the secrets of transcriptome engineering with Cas13.

How Can Core Labs Help You Get Started with NGS?

The Scientist’s Creative Services Team | 1 min read

Next-generation sequencing (NGS) core facility scientists and researchers new to NGS discuss their fruitful collaborations, highlighting how to receive expert help from genomics facilities.